Novartis Adakveo® receives positive CHMP opinion for the prevention of recurrent vaso-occlusive crises in patients with sickle cell disease

  • If approved, Adakveo would be the first targeted sickle cell disease therapy available for use in Europe

  • CHMP opinion supported by data showing Adakveo significantly reduced the rate of vaso-occlusive crises, with patients on Adakveo spending fewer days in hospital

  • Vaso-occlusive crises are sudden, unpredictable, and associated with an increased risk of organ damage and mortality1

Basel, July 24, 2020 — Novartis announced today that the Committee for Medicinal …

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Expanding CAR-T manufacturing in Europe to serve more patients

As we continue to expand our manufacturing capacity for transformative CAR-T cell therapy (Chimeric Antigen Receptor T-cell therapy), the European Medicines Agency (EMA) recently approved two European sites for commercial manufacturing. The sites located in Les Ulis, France, and Stein, Switzerland, will now support the supply of CAR-T cell therapy for patients in both commercial and clinical settings. This adds to the commercial capacity that already exists in our global network.

Commitment to patients

At Novartis, we are committed to serving advanced blood cancer patients …

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Breaking a vicious cycle of inflammation

In response to dry soil, a sensor in a garden triggers a sprinkler to deliver a shower of rain. Disaster strikes, though, if the sensor gets stuck in the “on” position. The shower turns into a stalled storm that floods the garden.

A similar problem can occur in the body. Immune cells contain danger sensors. They respond to danger with a sprinkling of signals that trigger healing inflammation. But if the danger sensor gets stuck on, the result is chronic inflammation that can cause more damage than good.

Novartis researchers aim to break this pattern by silencing part of the …

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